Breakthrough Medicines For Kidney Disease

Discover . Develop . Advance
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01

What We Do

149 Bio is a startup company developing breakthrough medicines to treat kidney diseases. We are using our proprietery platform to identify and devlop novel therapeutics.

02

Our Mission

At 149 Bio, our Mission is to discover and develop breakthrough medicines to treat Kidney Disease.

03

Our Vision

Our shared Vision is a world without the need for dialysis.

About

About Us

149 Bio is a startup company developing breakthrough medicines to treat kidney diseases.

 

  • ~14% of general population suffers fromChronic Kidney Disease (CKD) during their life time.
  • Diabetes and High Blood Pressure are leading causes of CKD.
  • Diabetic Nephropathy (DN) is growing globally.
  • Genetic changes result in CKD, such as Alport Syndrome, Focal Segmental Glomerulosclerosis (FSGS).
  • More than 660,000 Americans suffer from Kidney failure.
  • >90,000 patients/yr die due to Kidney Disease.
  • Better treatment options are urgently needed.
  • New therapeutics has been lacking due to shortage of good screening methods.
  • At 149 Bio, we have developed a novel proprietary platform to identify and develop novel therapeutic candidates.
  • Our platform allows rapid discovery of novel agent, as well as determine their mechanism of action to allow rapid drug development.

Our Team

Team 149 Bio is highly experienced in drug discovery and development.

A core expertise is in Kidney Disease.

 

Vineet Gupta, PhD

Founder, CEO

Vineet Gupta is the Founder and CEO of 149 Bio. He is also The Charles Weaver Chair for Cancer Research Professor and Vice Chair for Innovation in the Department of Internal Medicine at Rush University Medical Center, Chicago, IL. Vineet is a successful entrepreneur and has taken two startups from concept to exit. Most recently, his startup Adhaere Pharmaceuticals, Inc was acquired by GossamerBio. Vineet has extensive expertise in the field of integrins, high-throughput drug discovery and therapeutic development,and has been successful in taking compounds from discovery into the clinic. Vineet’s research is focused in the areas or auto-immune disease, kidney disease, cardiovascular diseases and oncology. He is widely published in high-impact peer-reviewed literature and has >50 patents/applications to his credit.  

Vineet received his Master’s of Science in Chemistry from the Indian Institute of Technology, Delhi (IIT Delhi) and his PhD in Chemistry from University of Rochester. He did his post-doctoral studies at The Rockefeller University and at Harvard Medical School. He previously held faculty positions at the Massachusetts General Hospital/Harvard Medical School and at University of Miami. He has also previously worked at various biotech companies.

Tony Barbosa, PhD

VP, Research

Tony Barbosa is the Vice President of Research at 149 Bio. Tony is an accomplished Medicinal Chemist, with expertise in small molecule drug discovery and development. He has designed/developed compounds against a number of highly validated targets, including several integrins, and has been successful in taking compounds from discovery into the clinic.

Tony received his Bachelor’s in Science from Providence College and his PhD in Organic Chemistry from the University of Rochester. Previously, he was Director of Chemistry at Adhaere Pharmaceuticals, Inc (acquired by GossamerBio). Tony is currently also the Chair of the Department of Chemistry & Physics at Ave Maria University. He has also worked at various pharmaceuticals and biotech companies in the past.

Our Kidneys

Kidneys are the essential organs in our body that filter waste from blood. Each of our two kidneys contain a million tiny cellular sieves, called nephrons, that filter urine away from blood. Being part of our cardiovascular system, other systemic changes, such as diabetes, hypertension, high fat diet and obesity, negatively impacts the normal function of the kidney. Additionally, certain genetic mutations or environmental stressors pose a threat to the kidney and reduce kidney function. Collective knowledge in the kidney field has identified a number of cellular and molecular pathways and targets that can now be effectively targeted with novel therapeutics.

Target Disease Areas

Diabetic Nephropathy (DN)

Lupus Nephritis (LN)

Alport Syndrome (AS)

Focal Segmental Glomerulosclerosis (FSGS)

Nephrotic Syndrome (NS)

Stats

Kidney Disease By the Numbers

# of Nephrons per Human Kidney

Patients with Kidney Failure

General Population suffers from Kidney Disease

Number of Approved New Medicines

Our Platform Technologies

We are utilizing our unique and proprietary Drug Discovery Platform to identify and advance novel candidate therapeutics.

Career Opportunities

149 Bio is growing. Please see the link below for current openings.

Our Office

149 Bio, LLC
1951 NW 7th Avenue, Suite 600            Miami, FL 33136

Contact Us                              

info@149bio.com 

© 2020 149 Bio LLC.       All rights reserved