A Clinical Stage Kidney Company

Targeting Integrins with Allosteric Activators as Therapeutics
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149 Bio announces acquisition of clinical stage integrin activator program from Gossamer Bio 

  • Clinical asset planned to be advanced in Lupus Nephritis and other indications
  • Program includes first-in-class integrin activator for myeloid cell integrin CD11b
  • CD11b activation reduces myeloid overactivation and tissue damage
  • Target validated in multiple auto-immune diseases and oncology

Miami, FL, February 23, 2023 (PRWeb) – 149 Bio, LLC, a clinical-stage therapeutics company focused on developing breakthrough treatments for kidney diseases and other immune conditions with high unmet need, announced today that it has acquired GB1275, a first-in-class orally bioavailable integrin activator, and the associated CD11b program in its entirety from Gossamer Bio, Inc.

The company plans to advance GB1275 in multiple therapeutic indications, including Lupus Nephritis (LN). GB1275 has the potential to reduce innate immune cell driven autoimmunity in multiple therapeutic areas and significantly improve patients’ lives. It is the first of its kind integrin activator to have entered the clinic.

“Over-exuberant innate immune cell response incites autoimmunity and end-organ injury in multiple autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) and Lupus Nephritis. Targeting key integrin receptor CD11b via the highly novel integrin activator GB1275 has been shown to significantly reduce myeloid cell activity in circulation and leukocyte infiltration in tissues, thereby reducing autoimmune damage,” said 149 Bio founder and CEO Vineet Gupta, PhD.

He continues that, “the acquisition of GB1275 and associated CD11b program, a potentially transformative therapeutic mechanism for autoimmune diseases and other indications, is consistent with our strategy to develop highly differentiated therapeutics to target integrin receptors in a variety of disease areas. We are especially focused on developing novel therapeutics for kidney diseases, to improve care for patients with urgent, unmet needs in these areas.”

The terms of the agreement were not publicly disclosed.

About 149 Bio, LLC

149 Bio is a privately held therapeutics company that is focused on targeting integrin receptors with a highly differentiated mechanism of action – allosteric activation. The company is leveraging pioneering discoveries of its co-founder Vineet Gupta, PhD, who was among the first to develop allosteric activators of integrins. Dr. Gupta’s research has shown that this is a highly differentiated therapeutic modality for targeting integrins. The company has also developed a proprietary CellStaple platform that enables discovery and validation of novel candidates. The company is using this platform for rapid identification and development of allosteric agonists against multiple different integrin targets and has a pipeline of different therapeutic programs in various stages of development.

Investor and Media Contact:

Santiago Balza Pineda




149 Bio announces nomination of integrin a3b1 as a target for its unique agonist antibodies as therapeutics for kidney disease 

  • Podocytes are lost in urine in many kidney diseases and its integrin receptor a3b1 keeps them in place
  • The company has identified novel allosteric agonist antibodies against a3b1 to anchor podocytes
  • Integrin a3b1 specific agonist antibodies expected to move to clinical testing stage in 2023

Miami, FL, October 10, 2022 (PRWeb) – 149 Bio, LLC has announced its therapeutic target for kidney diseases as integrin heterodimer alpha3beta1 (a3b1) that is highly expressed on kidney podocytes and is essential for podocyte attachment and health. The company also disclosed identification of novel allosteric agonist antibodies that target integrin a3b1 and enhance integrin-dependent ligand binding and cell adhesion.

Human kidney is a bean-shaped organ in the body that filters blood, by removing waste and excess fluids from the body via urine. Each of the body’s two kidneys is made up of a million tiny filters called nephrons, with a glomerulus as its main filtration apparatus. In turn, each glomerulus is composed of thousands of unique cells, called podocytes, that stick to the outside of tiny blood vessels and form an inter-digitating meshwork that forms the kidney’s molecular filter. a3b1 is the key integrin on the surface of podocytes that mediates podocyte attachment to the outside of blood vessels and form a healthy glomerulus. Progressive loss of podocytes in disease, via de-adhesion and injury, is a hallmark of multiple glomerular diseases, such as Focal Segmental Glomerulosclerosis (FSGS).

Since the integrin a3b1 mediates podocyte adhesion, activating integrin a3b1 may act as a compensatory mechanism in glomerular diseases, by helping stabilize podocyte attachment, preventing cell loss in the urine, and thereby providing protection from loss in kidney function. Indeed, prior research from the laboratory of 149 Bio’s co-founder, Vineet Gupta, PhD, has shown that certain integrin agonists help protect the podocytes and the kidney from injury and disease. Thus, the company developed an assay platform to discover agonist antibodies targeting a3b1 and has identified several novel antibodies.

The company expects to present some of the initial findings from this research at an upcoming international conference. The company anticipates moving its lead a3b1 allosteric agonist antibody candidate into clinical trials in 2023.

Please send inquiries to: media@149bio.com 

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